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Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01 and R21 Clinical Trial Optional)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.307
National Cancer Institute, National Institute of Mental Health, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Institute on Minority Health and Health Disparities, National Institutes of Health, U.S. Department of Health and Human Services
May 8, 2021

Lists of scientific/research and financial/grants management contacts by research area are available in the application instructions.


This program provides research grants that address patient adherence to treatment and prevention regimens to promote positive health outcomes. Clinical trials are optional.

Research topics and intervention approaches may include, but are not limited to:

  • Testing innovative approaches for monitoring and maintaining individual or caregiver adherence to complex healthcare regimens
  • Interventions for target groups at high risk for non-adherence, such as adolescents/young adults and individuals with cognitive impairment, complex illnesses and health regimens, mental health comorbidities, and/or substance abuse
  • Social and structural determinants of health contributing to racial and ethnic disparities in adherence and associated health outcomes
  • Examine the role of shared decision making on adherence

The National Institute of Minority Health and Health Disparities is interested in supporting research and interventions considering determinants from more than one domain or level of influence. Research must focus on one or more minority or health disparity population:

  • African Americans
  • Hispanics/Latinos
  • American Indians/Alaska Natives
  • Asians, Native Hawaiians and Other Pacific Islanders
  • Socioeconomically disadvantaged populations
  • Underserved rural populations
  • Sexual and gender minority populations

Research objectives, methodology, and examples of topics are described in detail in the application instructions.

  1. R21 Exploratory/Developmental Research Grant for the development of new research activities in the early and conceptual stages
  2. R01 Research Project Grant that supports a discrete project to be performed by an investigator in an area representing the investigator's specific interest and competencies

Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Non-domestic entities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. Territories
Amount of funding

For R21 projects, the combined budget for direct costs for the 2-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

R01 project budgets are not limited but need to reflect the actual needs of the proposed project.

Application process

Links to the full announcement and online application procedures are available on

Note: This opportunity is listed under 2 Funding Opportunity Announcement Numbers (PA-18-723 for R21 and PA-18-722 for R01) and a series of Catalog of Federal Domestic Assistance (CFDA) Numbers based on research area.

R01 applicants requesting $500,000 or more in direct costs in any year must discuss the project with the appropriate scientific/research contact at least 6 weeks before submitting the application.

Standard deadlines apply for new R21 applications and for new, renewal, resubmission, and revision R01 applications.

Standard AIDS deadlines apply for all activity codes.

Tagged as
Alcohol use · American Indian or Alaska Native · Asian · Black or African American · Cancer · Children and youth · HIV and AIDS · Health disparities · Hispanic or Latino · Illicit drug use · LGBT · Mental health · Minorities · Native Hawaiian or Pacific Islander · People with disabilities · Poverty · Racial and ethnic groups · Research methods and resources · Social determinants of health · Substance use and misuse

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.