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Addressing the Challenges of the Opioid Epidemic in Minority Health and Health Disparities Research in the U.S. (R01 and R21)

Catalog of Federal Domestic Assistance Number: 93.307
National Institute on Minority Health and Health Disparities, National Institutes of Health, U.S. Department of Health and Human Services
Letter of Intent (Optional): Oct 13, 2020
Application: Nov 13, 2020

A list of agency contacts by research area may be found in the application instructions.


This opportunity provides funding for research focused on determining the mechanisms for the variation in the prevalence of opioid use disorder, and understanding and reducing disparities in opioid care in minority health and health disparity populations in the U.S.

Projects should include a focus on one or more NIH-designated health disparity populations, including:

  • Blacks/African Americans
  • Hispanics/Latinos
  • American Indians/Alaska Natives
  • Asians, Native Hawaiians, and other Pacific Islanders
  • Socioeconomically disadvantaged populations
  • Underserved rural populations
  • Sexual and gender minorities

Potential research topic areas include, but are not limited to:

  • Assess the relationship between access to chronic pain treatment in health disparity populations and Opioid use disorder (OUD)
  • Evaluate the relationship between opioid prescribing and OUD demographics, specifically relating to race and ethnicity
  • Evaluate the use of MAT in non-traditional settings
  • Evaluate the intersection of OUD with mental health disorders
  • Research on pharmacogenomic testing in OUD treatment
  • Developing specialized MAT maintenance programs for pregnant women with OUD
  • Healthcare delivery and access in rural areas among middle-aged and older Americans
  • Opioid use in nursing homes and other residential care facilities
  • The role of alcohol use in the development of opioid addiction, morbidity, and mortality

A more detailed list of potential research topics is provided in the application instructions.

There are two funding opportunities under this program:

  1. R21 Exploratory/Developmental Research Grant for the development of new research activities in the early and conceptual stages
  2. R01 Research Project Grant that supports a discrete project to be performed by an investigator in an area representing the investigator's specific interest and competencies

Eligible applicants include

  • State, county, city, township, territory, or special district governments
  • Independent school districts
  • Public and private institutions of higher education
  • Federally recognized or other than federally recognized tribal governments
  • Public and Indian housing authorities
  • Native American tribal organizations
  • Nonprofits with or without 501(c)(3) status, faith-based, and community-based organizations
  • For-profit organizations and small businesses
Geographic coverage
Nationwide and U.S. Territories
Amount of funding

The combined budget for R21 project direct costs for the 2 year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

R01 project budgets are not limited, but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

Application process

Links to the full announcement and online application procedures are available on

While not required, potential applicants are encouraged to email a letter of intent to Andrew Louden, Ph.D. 30 days prior to the application deadline.

Tagged as
American Indian or Alaska Native · Asian · Black or African American · Health disparities · Hispanic or Latino · Illicit drug use · LGBT · Minorities · Native Hawaiian or Pacific Islander · Poverty · Prescription drug misuse · Racial and ethnic groups · Research methods and resources

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.