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Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34 )

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.279
National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services
Jan 7, 2021

Scientific research contacts:

Amy B. Goldstein, PhD
National Institute on Drug Abuse

Dr. Beverly Ruffin
National Institute on Alcohol Abuse and Alcoholism

Financial and grants management contacts:

Edith Davis
National Institute on Drug Abuse

Judy Fox
National Institute on Alcohol Abuse and Alcoholism


This program provides funding for:

  • Pre-trial feasibility and acceptability testing for prevention services and systems research
  • Pilot and/or feasibility testing of:
    • Innovative new, revised, or adapted prevention intervention approaches to prevent or delay the initiation and onset of drug and alcohol use
    • The progression to misuse or problem use of alcohol and other substances
    • Strategies to reduce drinking and driving and deaths related to impaired driving
    • The prevention of suicide attempts
    • Drug or alcohol related acquisition or transmission of HIV infection and viral hepatitis among diverse populations and settings

Specific areas of research interest include, but are not limited to:

  • Feasibility and pilot testing of screening and universal brief intervention models to prevent alcohol and drug use and misuse (including opioid misuse and opioid use disorder) for delivery in medical settings and the broader healthcare system
  • Development and pilot testing of novel drug and alcohol use prevention interventions for delivery in healthcare settings, particularly settings that serve persons at high risk for substance use problems
  • Development and pilot testing of innovative strategies, approaches, policies to prevent opioid and other prescription drug misuse and opioid use disorder and related problems for populations across the lifespan and in settings most impacted by the opioid crisis
  • Studies that test strategies for prevention of opioid misuse and opioid use disorders in the context of medical treatment for and management of pain
  • Development and pilot testing of environmental and community intervention strategies within and across health, justice, education, community and social service settings, where the benefits of multi-level strategies to prevent substance use/misuse and abuse, HIV infection, and related morbidity and high-risk behaviors could be explored
  • Studies that evaluate the application of new technologies and modalities for delivering, implementing, and testing prevention interventions, particularly for difficult to reach populations and settings (including at-risk and stigmatized populations and rural settings)

Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Non-domestic entities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. territories
Amount of funding

Applicants may request direct costs of up to $450,000 for a maximum project period of 3 years. No more than $225,000 in direct costs may be requested each year.

Application process

Links to the program guidance and electronic application are available through

Standard NIH application due dates for new R34 applications apply to this funding opportunity. Standard AIDS dates apply for AIDS and AIDS-related applications.

This program is listed under a single Funding Opportunity Number (PA-18-775) and 2 CFDA numbers.

  • 93.273 - Alcohol Research Programs
  • 93.279 - Drug Abuse and Addiction Research Programs
Tagged as
Alcohol use · HIV and AIDS · Health screening · Illicit drug use · Injuries · Prescription drug misuse · Research methods and resources · Stigma · Substance use and misuse · Wellness, health promotion, and disease prevention

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