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End-of-Life and Palliative Care Approaches to Advanced Signs and Symptoms (R01 and R21 Clinical Trial Optional)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.361
National Institute of Nursing Research, National Institutes of Health, U.S. Department of Health and Human Services
Jan 8, 2022

Scientific/research contact:
Karen A. Kehl, Ph.D.

Peer review contact:
Peer review contact information will appear in the applicant's eRA Commons account approximately 2 weeks after the submission date.

Financial and grants management contact:
Ron Wertz


This program provides funding for research to examine the multi-dimensional foundations, experiences, and management of complex, advanced signs and symptoms at the end of life. Projects that include under-studied populations including NIH-designated health disparity, socioeconomically disadvantaged, rural and/or remote, and sexual and gender minority populations with advanced, serious illness at the end of life are specifically encouraged.

Research projects of interest include, but are not limited to:

  • The mechanisms of complex advanced signs and symptoms at the end-of-life that may be modified to improve the symptom experience of the individual or family
  • The complex variables affecting the symptom experience including physiological, social, cultural, and emotional variables and confounding variables such as other symptoms and underlying disease
  • How type, intensity, complexity, and changes in trajectory of advanced symptoms impact individual and family goals for care
  • Develop, test and evaluate efficient, effective strategies for management of complex, advanced signs and symptoms at the end-of-life, including non-pharmacological interventions and current medications
  • The impact of advanced signs and symptoms on the seriously ill person and/or the family caregiver
  • Explore and describe the roles of the ill person and the family caregiver in identifying, assessing and communicating with clinicians about advanced signs and symptoms

There are two funding opportunities under this program:

  1. R21 Exploratory/Developmental Research Grant for the development of new research activities in the early and conceptual stages
  2. R01 Research Project Grant that supports a discrete project to be performed by an investigator in an area representing the investigator's specific interest and competencies

Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Non-domestic entities and non-domestic components of U.S. entities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. territories
Amount of funding

R21: The combined budget for direct costs for the 2 year project period may not exceed $275,000. No more than $200,000 in direct costs may be requested in any single year.

R01: Project budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

Application process

Links to the full announcement and online application procedures are available on

Submission dates for all non-AIDS applications may be found on the Standard Due Dates web page. Be aware that there are different standard deadlines for new R21 and R01 projects.

Submission dates for all AIDS and AIDS-related applications may be found on the Standard AIDS Due Dates web page.

This opportunity expires on January 8, 2022.

Tagged as
Frontier and remote areas · Health disparities · Hospice and palliative care · LGBTQ+ · Poverty · Research methods and resources

Organizations (2)

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