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HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (UG3/UH3, Clinical Trials Optional)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.307
National Cancer Institute, National Institute on Aging, National Institute on Minority Health and Health Disparities, National Institutes of Health, U.S. Department of Health and Human Services
Letter of Intent (Optional): Feb 29, 2020
Application: Mar 30, 2020

This program provides funding to support the "real world" assessment of healthcare strategies, clinical practices, and procedures in healthcare systems that may lead to improved pain management along with a reduction in unnecessary opioid prescribing.

Research areas of interest include:

  • Improving pain management in emergency rooms, dental clinics, primary care settings, or hospitals
  • Specific patient populations including individuals with acute/chronic pain who have or are at risk of opioid use disorder, individuals with pain and a co-occurring mental health disorder, and individuals with chronic overlapping pain conditions
  • The effect of system level innovations to improve implementation of established guidelines for non-opioid approaches to pain management and comorbid conditions or methods to manage opioid prescribing in a safe and effective manner
  • Comparative effectiveness studies utilizing different combinations of pain management treatments for chronic pain within healthcare systems
  • Implementation strategies to support the adoption and integration of effective pain management clinical procedures or guidelines into existing care systems
  • Identify effective implementation strategies for integrating multiple evidence-based practices within community or clinical settings to meet the needs of pain patients and diverse systems of care
  • The effectiveness and impact on utilization of health care services of implementation strategies to reduce health disparities and improve quality of pain management among rural, minority, low literacy and numeracy, and other underserved populations

Awards will initially support a one-year, milestone-driven, planning phase (UG3), with possible transition to an implementation phase (UH3) of up to 4 years duration.


Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. territories
Amount of funding

The application budget for the UG3 phase is limited to $500,000 each year in direct costs. Costs for each year of the UH3 phase are limited to $1,000,000 per year in direct costs.

The UG3 phase is limited to up to one year and the UH3 phase can request up to 4 years of support. The total project period may not exceed 5 years.

Estimated number of awards: 2
Estimated total program funding: $1,200,000

Application process

Links to the full announcement and online application process are available through

While not required, potential applicants are encouraged to email a letter of intent to Martina Schmidt, Ph.D. by February 29, 2020.

Tagged as
Aging and aging-related services · Cancer · Emergency department and urgent care services · Health disparities · Healthcare facilities · Mental health · Minorities · Oral health · Prescription drug misuse · Primary care · Research methods and resources

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.