sciencequestions@pcori.org
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This program provides funding to support innovative studies in patient-engaged and patient-centered comparative clinical effectiveness research and the impact of COVID-19.

Priority areas include:

• Adaptations to healthcare delivery:
  • What has been the impact on patient-centered outcomes of alternative healthcare delivery models that are being implemented in response to COVID-19?
  • What has been learned about barriers and facilitators to their effective implementation?
• Impact of COVID-19 on vulnerable populations:
  • What are effective clinical pathways to improve outcomes for the most vulnerable and higher risk patients?
  • What are effective system- or organizational-level responses to prevent or mitigate the impact of COVID-19 in low-income and low-resource settings that serve vulnerable populations?
  • Vulnerable populations include but are not limited to Native Americans or Alaskan Natives, African Americans, and other racial, ethnic, or sexual and gender minorities; rural communities; incarcerated populations; people who are homeless or unstably housed; individuals with intellectual, developmental, or physical disabilities; individuals with chronic conditions; and individuals facing increased exposure because they are unable to work remotely.
• Impact of COVID-19 on healthcare workforce well-being, management, and training:
  • What policies, practices, or programs are effective in helping health systems quickly shift human resources, redeploy healthcare workers, and train current and new healthcare workers to fill certain healthcare delivery needs?
  • What are effective strategies to protect the physical and/or mental well-being of the healthcare workforce?

Eligible applicants include any public or private-sector research organization, including:

• Nonprofit organizations
• For-profit organizations
• University and college hospitals and healthcare systems
• Laboratories and manufacturers
• Units of local, state, and federal government

Award ceiling: Up to $2,500,000 for small studies and up to $5,000,000 for large studies

Project period: 2 years
Investigators are encouraged to complete primary outcomes collection and provide actionable findings in no longer than 12 months.

Links to additional guidance, application instructions, and the online application portal are available on the program website.