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Rural Health Information Hub

New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional and R01 Clinical Trial Required)

Catalog of Federal Domestic Assistance Number: 93.279
National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services
Mar 19, 2025

Scientific/research contact:
Minnjuan Flournoy Floyd, PhD

Peer review contact:
Dharmendar Rathore, PhD

Financial and grants management contact:
Garlin Hallas


This program awards research grants to support the development and testing of enhanced models of care that integrate HIV, Hepatitis B and C, addiction, and primary care services.

Research objectives and specific areas of interest:

  • Test implementation strategies or models to integrate evidence-based substance misuse prevention or substance use disorder (SUD) treatment interventions in HIV care settings
  • Apply implementation science approaches to translate strategies with demonstrated efficacy or effectiveness in other settings or locations
  • Test integrated HIV/AIDS and SUD care models that leverage innovative approaches to incorporate social network components such as peer recovery coaches
  • Test integrated HIV/AIDS and SUD care approaches that capitalize on electronic health record systems and other efforts to increase integration within and between health systems
  • Test methods for improving the coordination and communication between behavioral health and HIV care providers within and across settings
  • Test implementations of direct service and consultation models of e-Health as primary modalities of integrated HIV/AIDS & SUD care in resource constrained environments
  • Examine interventions that implement substance use screening, brief intervention and linkage to SUD treatment from settings serving persons at high risk for HIV and Hepatitis such as sexually transmitted infection clinics
  • Examine syringe service programs as hubs for providing HIV prevention and care and linkage to SUD treatment
  • Test integrated care models that consider polypharmacy in aging adults living with HIV and have SUD pain management using alternatives to opioids, drug toxicities and interactions, simplified treatment regimens to prevent the risks of polypharmacy
  • Test integrated models of HIV and SUD service delivery that ensure care continuum and increase quality of life through transitions of care for older adults living with HIV
  • Test integrated care models that address multimorbidity and substance use unique to older adults living with HIV

There are two funding opportunities under this program:

  • R34 Planning Grant for the initial development of a clinical trial or research project.
  • R01 Research Project Grant that supports a discrete project to be performed by an investigator in an area representing the investigator's specific interest and competencies

Projects are encouraged that propose research in states and counties identified in the federal Ending the HIV Epidemic initiative, including areas with the highest rural HIV burden.


Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
    • Hispanic-serving institutions
    • Historically Black Colleges and Universities (HBCUs)
    • Tribally Controlled Colleges and Universities (TCCUs)
    • Alaska Native and Native Hawaiian Serving Institutions
    • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Non-domestic entities and non-domestic components of U.S. entities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. Territories
Amount of funding

R34: Direct costs are limited to $450,000 over the 3-year project period. No more than $225,000 in direct costs are allowed in any single year.

R01: Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

Application process

Links to the full announcement and online application process are available through

Tagged as
American Indian or Alaska Native · Asian · Black or African American · HIV and AIDS · Hispanic or Latino · Infectious diseases · Integrated service delivery · Native Hawaiian or Pacific Islander · Primary care · Racial and ethnic groups · Research methods and resources · Substance use and misuse · Technology for health and human services

Organizations (3)

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.