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Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 Clinical Trial Optional)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.307
National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of Mental Health, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Institute on Minority Health and Health Disparities, National Institutes of Health, U.S. Department of Health and Human Services
Letter of Intent (Optional): Jul 20, 2021
Application: Aug 24, 2021

This program provides grants for observational research to understand the role of structural racism and discrimination in causing and sustaining health disparities and intervention research that addresses structural racism and discrimination (SRD) to improve minority health and reduce health disparities.

The funding opportunity description section of the application instructions provides research objectives and specific areas of research interest under the topics:

  • Minority health and health disparities
  • Complementary and integrative health approaches for improving minority health and eliminating disparities in health conditions such as mental health, emotional well-being, behavioral health, and/or pain
  • Cancer related disparities and promoting equity in cancer prevention, diagnosis, treatment, and survivorship
  • Preventing, treating, or reversing vision loss and addressing the special health problems and requirements of the visually impaired, with special emphasis on structural racism influences on the delivery of eye care in underserved populations
  • Impacts and strategies for addressing SRD at various levels of influence within and across organizations, institutions, or groups that directly and indirectly contribute to health disparities in genomic medicine
  • Studies to address structural racism to improve heart, lung, and blood diseases and sleep disorders
  • Understanding the environmental, sociocultural, behavioral, and biological drivers of health inequities and disparities related to aging, Alzheimer's Disease, and related dementias
  • Impact of SRD on the development, course, and recovery from alcohol misuse, alcohol use disorders, substance use disorders, substance use consequences, and comorbid conditions including HIV
  • Impact of SRD on HIV/AIDS, allergy, immunology, infectious diseases, arthritis, musculoskeletal, and skin diseases
  • Maternal and infant mortality and morbidity, adolescent and young adult mortality and morbidity; contraceptive use and non-use; reproductive health, gynecological health, and fertility for populations of interest
  • Health equity and reducing and eliminating health disparities relevant to diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases
  • Environmental health disparities
  • Assessment of interventions modifying structural racism and discrimination and how these changes result in improvement in mental health outcomes

Designated populations with health disparities include racial and ethnic minorities, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities.


Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. Territories
Amount of funding

Application budgets are limited to $500,000 annually, for a maximum project period of 5 years.

Available funding and the anticipated number of awards by national institute is listed in the award information section of the application instructions.

Application process

Links to the full announcement, application instructions, and the online application process are available through

While not required, potential applicants are encouraged to email a letter of intent to Yujing Liu, MD, PhD by July 20, 2021.

Tagged as
Aging and aging-related services · Arthritis · Behavioral health · Cancer · Cardiovascular disease · Chronic respiratory conditions · Dementia · Depression · Diabetes · Environmental health · HIV and AIDS · Health disparities · Infectious diseases · LGBTQ+ · Maternal health and prenatal care · Mental health · Minorities · Obesity and weight control · Oral health · Poverty · Racial and ethnic groups · Research methods and resources · Sexual and reproductive health · Substance use and misuse · Vision impairment · Women

Organizations (10)

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.