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Enhancing Social Connectedness and Ameliorating Loneliness to Prevent and Treat SUD and Support Recovery (R21 - Clinical Trial Not Allowed)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.279
National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services
Aug 15, 2022

Scientific/research contact:

Carrie Mulford

Aria Crump

Peer review contact:
Dharmendar Rathore, PhD

Financial and grants management contact:
Pam Fleming


The National Institute on Drug Abuse will provide funding for exploratory/developmental research to better understand the role of social connectedness and/or loneliness in prevention, treatment, and recovery from substance use disorders (SUDs).

Examples of research questions of interest include, but are not limited to:

  • How are social connectedness and loneliness related to other measures of social relationships, like social networks and social support, particularly as it relates to associations with substance use behaviors?
  • How do the dynamics of social connectedness/loneliness change for different demographic groups, such as men vs. women; across different stages of the lifespan; in rural vs. urban communities; and across different racial and ethnic groups?
  • How do issues of equity influence dynamics of social connectedness and loneliness in the context of substance use initiation, escalation, treatment, and recovery?
  • How do changes in online or offline social networks affect loneliness and in turn influence substance use behaviors?
  • Knowing that some social connections exacerbate substance use and thwart treatment and recovery efforts, how can the dynamics of positive and negative influences of social connections both ameliorate loneliness and improve substance use outcomes?
  • How do changes in social networks and social connectedness influence the dynamics of recovery? Are there particular inflection points (such as post-incarceration or post inpatient recovery) that are especially amenable to intervention?

Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. Territories
Amount of funding

Award ceiling: $275,000 over the entire project period, with no more than $200,000 in direct costs allowed in any single year
Project period: 2 years
Estimated number of awards: 3-4
Estimated total program funding: $750,000

Application process

Links to the full announcement, application instructions, and the online application process are available through

Tagged as
Racial and ethnic groups · Research methods and resources · Substance use and misuse

Organizations (3)

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