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Strategic Prevention Framework for Prescription Drugs (SPF Rx)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.243
Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services
Apr 25, 2022

For program and eligibility questions:
Matthew Clune

For fiscal and budget questions:

For grant review process and application status questions contact:
Gabriela Porter


The Strategic Prevention Framework for Prescription Drugs (SPF Rx) grant program provides funding to help prevent and address prescription drug misuse within a state, tribe, or locality. The program is designed to raise awareness about the dangers of sharing medications, the risks of fake or counterfeit pills purchased over social media or other unknown sources, and work with pharmaceutical and medical communities on the risks of overprescribing.

Required activities include:

  • Utilize the Strategic Prevention Framework (SPF) process to actively engage community members, healthcare providers, key stakeholders, adult, youth, young adults, elders, spiritual advisors, and tribal leaders
  • Identify any new groups within the state, tribe, or community that need to receive training on the potential risks of sharing and overprescribing medications, including the risk of fake and counterfeit pills being sold online or through other unknown sources
  • Raising community awareness by bringing prescription drug abuse prevention activities and education to schools, communities, parents, prescribers, and their patients
  • Develop and implement a community-based social marketing/public education plan to increase awareness of prescription drug misuse issues, the need for a coordinated approach, and promote increased use of data

Additional activities are listed in the application instructions.

Through this opportunity, SAMHSA will also track reductions in opioid overdoses and the incorporation of Prescription Drug Monitoring Program (PDMP) data into needs assessments and strategic plans as indicators of the program's success.


Eligible applicants include domestic public and private nonprofit entities, such as:

  • State governments and the District of Columbia
  • Federally recognized American Indian/Alaska Native (AI/AN) tribes, tribal organizations, Urban Indian Organizations, and consortia of tribes or tribal organizations
  • Community- and faith-based public and private nonprofit organizations
  • Public and private universities and colleges
Geographic coverage
Nationwide and U.S. Territories
Amount of funding

Award ceiling: $500,000 per year
Project period: Up to 5 years
Estimated number of awards: 6
Estimated total program funding: $3,000,000

Application process

Links to the full announcement, application instructions, and the online application process are available through

Tagged as
American Indian or Alaska Native · Children and youth · Families · Networking and collaboration · Planning and strategy methods and resources · Prescription drug misuse · Schools · Substance use and misuse

Organizations (2)

  • U.S. Department of Health and Human Services, view details
  • Substance Abuse and Mental Health Services Administration, view details

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.