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Strategic Prevention Framework for Prescription Drugs (SPF Rx)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.243
Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services
Apr 30, 2021

For program questions:
Jerry Campbell

For grants management and budget questions:
Corey Sullivan


The Strategic Prevention Framework for Prescription Drugs (SPF Rx) grant program provides funds for state agencies, territories, and tribal entities that have completed a Strategic Prevention Framework State Incentive Grant or a similar state plan to target prescription drug misuse.

Required activities include:

  • Raising awareness about the dangers of sharing medications, and work with pharmaceutical and medical communities on the risks of overprescribing to young adults
  • Raising community awareness by bringing prescription drug abuse prevention activities and education to schools, communities, parents, prescribers, and their patients

Additional activities are listed in the application instructions.

Through this opportunity, SAMHSA will also track reductions in opioid overdoses and the incorporation of Prescription Drug Monitoring Program (PDMP) data into needs assessments and strategic plans as indicators of the program's success. State applicants must have a fully operational PDMP in order to apply for the SPF Rx program. Tribes must coordinate with the state run PDMPs to identify opportunities for collaboration that will limit overprescribing in tribal communities.


Eligibility is limited to states, U.S. territories, and tribal entities that have completed a Strategic Prevention Framework State Incentive Grant or a similar state-level strategic plan for the prevention of prescription drug misuse. Applicants also are required to have an operational state run Prescription Drug Monitoring Program (PDMP).

Geographic coverage
Nationwide and U.S. Territories
Amount of funding

Award ceiling: $384,000 per year
Project period: Up to 5 years
Estimated number of awards: 26
Estimated total program funding: $10,000,000

Application process

Links to the full announcement, application instructions, and the online application process are available through

Tagged as
American Indian or Alaska Native · Children and youth · Families · Prescription drug misuse · Schools

For complete information about funding programs, including your application status, please contact funders directly. Summaries are provided for your convenience only. RHIhub does not take part in application processes or monitor application status.