Comprehensive Opioid, Stimulant, and Substance Use Site-Based Program
Office of Justice Programs Response
Center:
OJP.ResponseCenter@usdoj.gov
800.851.3420
JustGrants help desk:
833.872.5175
JustGrants.Support@usdoj.gov
Grants.gov contact center:
800.518.4726
support@grants.gov
Self-service knowledge base
System for Award Management (SAM):
866.606.8220
Federal service
desk
The Comprehensive Opioid, Stimulant, and Substance Use Site-Based Program (Short Title: COSSUP) provides grants to develop, implement, and/or expand comprehensive programs in response to to overdose deaths, illicit opioids, stimulants, or other substances. Through this program, state, territorial, local, and tribal governments can support law enforcement-related activities, including efforts to locate and investigate illicit activities related to the unlawful distribution of opioids; increase access to prevention programs and overdose reversal medications; and expand treatment and recovery support services in the community, within correctional facilities, and upon reentry.
Rural applicants should apply under Subcategory 1c for projects in rural areas as defined by the Rural Health Grants Eligibility Analyzer. Jurisdictions not designated as rural via this tool but have a population of less than 100,000 should apply in Subcategory 1b.
Funds may be used for:
- Locating or investigating illicit activities related to the unlawful distribution of opioids
- Pre-booking or post-booking alternative-to-incarceration treatment programs that serve individuals at high risk for overdose or substance abuse
- Law enforcement and other first responder diversion programs, including multidisciplinary overdose prevention, response, and diversion and referral programs
- Education and prevention programs to connect law enforcement agencies with K–12 students
- Prescription drug take-back programs for unused controlled substances found in the home and used by hospitals, long-term care facilities, and other facilities
- Naloxone, including training on the use of naloxone, for law enforcement, first responders, criminal justice professionals, and communities
- Court-based intervention programs or family court programming to prioritize and expedite treatment and recovery services to individuals at high risk for overdose
- Evidence-based treatment, such as medications for opioid use disorder, as well as recovery support services including transitional or recovery housing and peer recovery support services
- Comprehensive, real-time, regional information collection, analysis, and dissemination
A detailed list of funding priorities is provided in the application instructions.
Eligible applicants are city, township, county, state, special district, federally recognized tribal governments, and other units of local government.
To be eligible under the rural subcategory, a jurisdiction must be defined as rural by HRSA's Rural Health Grants Eligibility Analyzer.
Rural Subcategory (1c):
Anticipated award amount: $1,600,000
Estimated number of awards: 13
Project period: 3 years
Tribal Category (3):
Award ceiling: $1,000,000
Estimated number of awards: 11
Project period: 3 years
Estimated total program funding: $133,585,276
Links to the full announcement, application instructions, and the online application process are available through grants.gov.
Applicants should submit an SF-424 in grants.gov by September 24, 2026.
Submit the full application, including attachments, in the JustGrants grants management system by October 1, 2026.
For complete information about funding programs, including your
application status, please contact funders directly. Summaries are provided
for your convenience only. RHIhub does not take part in application processes
or monitor application status.