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Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional)

This funding record is inactive. Please see the program website or contact the program sponsor to determine if this program is currently accepting applications or will open again in the future.

Catalog of Federal Domestic Assistance Number: 93.307
National Institute on Minority Health and Health Disparities, National Institutes of Health, U.S. Department of Health and Human Services
Letter of Intent (Optional): Mar 3, 2023
Application: Apr 3, 2023

Scientific/research contact:
Nathan Stinson Jr, MD, PhD, MHP

Peer review contact:
Yujing Liu, MD, PhD

Financial and grants management contact:
Priscilla Grant, JD


This program provides research grants for projects that test the effectiveness of multi-level interventions to prevent HIV in high-risk health disparity populations or subgroups in one or more geographic areas with a high rate of new HIV infections.

Areas of special interest include, but are not limited to:

  • Testing of interventions in multiple geographic hot spots
  • Use of cluster randomized trials or multi-site quasi-experimental studies
  • Interventions that include clinician- or healthcare setting-level intervention components to enhance cultural competency, reduce health-care related stigma and discrimination, and increase clinician comfort and willingness to prescribe PrEP
  • Engagement of community members of the target high-risk health disparity populations or subgroups as investigators, advisors, or peer interventionists
  • Collaboration with diverse local stakeholders in addition to HIV-prevention service providers, including school systems, school-based student or parent associations, community-based organizations, consumer organizations, and faith-based organizations, to enhance intervention relevance, feasibility, and sustainability
  • Projects that examine cost-effectiveness of intervention implementation and delivery

The largest population focus is HIV-negative men who have sex with men (MSM) and/or transgender women who are African American or Latino/a. Other disparity populations include non-Hispanic White MSM, cisgender Black or Latina women, and rural residents who inject drugs.


Eligible applicants include:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Small businesses
    • For-profit organizations
Geographic coverage
Nationwide and U.S. territories
Amount of funding

Application budgets are limited to $750,000 in direct costs annually.

The maximum project period is 5 years.

Application process

Links to the full announcement, application instructions, and the online application process are available through

While not required, potential applicants are encouraged to email a letter of intent to Yujing Liu, MD, PhD by March 3, 2023.

Tagged as
Black or African American · Culture and cultural competency · HIV and AIDS · Health disparities · Hispanic or Latino · Illicit drug use · LGBTQ+ · Networking and collaboration · Research methods and resources · Stigma · Wellness, health promotion, and disease prevention · White

Organizations (3)

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