Patient-Centered Outcomes Research Institute (PCORI) Funding: Broad Pragmatic Studies
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sponsor to
determine if this program is currently accepting applications or will open again in the future.
Application: Jan 13, 2026
This program provides funding to support investigator-initiated proposals for patient-centered comparative clinical effectiveness research projects designed to inform patients, caregivers, clinicians, and other healthcare stakeholders in making personalized clinical decisions across a wide range of conditions, populations, and treatments.
Projects must align with at least one of the PCORI National Priorities for Health.
Special research areas of interest for this funding cycle include studies focused on menopause, maternal sleep health, and mental/behavioral health challenges of people living with Alzheimer's disease and related dementias.
Funding available under category 3 supports studies that leverage PCORnet® to advance PCORI's national priorities.
Populations of interest include residents of rural areas.
Eligible applicants include academic research, private sector research, or study-conducting entities. This may include agencies and instrumentalities of the federal government, nonprofit/for-profit research organizations, and colleges/universities, among others.
Funding amounts:
- Category 1 awards up to $5,000,000
- Category 2 awards between $5,000,000 - $12,000,000
- Category 3 awards up to $12,000,000 for studies that leverage PCORnet® to advance PCORI's national priorities
Project period: Up to 5 years
Links to additional guidance, application instructions, and the online application portal are available on the program website.
Applicants must submit a letter of intent through the online system by September 23, 2025. Selected applicants will be invited to submit a full application, with a deadline of January 13, 2026.
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application status, please contact funders directly. Summaries are provided
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