Patient-Centered Outcomes Research Institute (PCORI) Funding: Broad Pragmatic Studies
Application: Sep 1, 2026
This program provides funding to support investigator-initiated proposals for patient-centered comparative clinical effectiveness research projects designed to inform patients, caregivers, clinicians, and other healthcare stakeholders in making personalized clinical decisions across a wide range of conditions, populations, and treatments.
Projects must align with at least one of the PCORI research project agenda topic themes.
Special research areas of interest for this funding cycle include studies focused on diabetes prevention, care, and treatment; addressing obesity; management of urogynecological and pelvic pain; and pain management for individuals living with sickle cell disease.
Populations of interest include residents of rural communities.
Eligible applicants include academic research, private sector research, or study-conducting entities. This may include agencies and instrumentalities of the federal government, nonprofit/for-profit research organizations, and colleges/universities, among others.
Funding amounts:
- Category 1 awards up to $5,000,000
- Category 2 awards between $5,000,000 - $12,000,000
- Category 3 awards up to $12,000,000 for studies that leverage PCORnet® to advance PCORI's national priorities
Project period: Up to 5 years
Links to additional guidance, application instructions, and the online application portal are available on the program website.
Submit a letter of intent through the online system by April 28, 2026. Selected applicants will be invited to submit a full application, with a deadline of September 1, 2026.
For complete information about funding programs, including your
application status, please contact funders directly. Summaries are provided
for your convenience only. RHIhub does not take part in application processes
or monitor application status.