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Notice of Special Interest (NOSI): Research to Address Vaccine Uptake and Implementation among Populations Experiencing Health Disparities

National Institutes of Health, U.S. Department of Health and Human Services
Jun 6, 2026

Contact information by research topic is available on the program website.


This opportunity is a Notice of Special Interest (NOSI) for research on strategies and interventions to increase vaccine uptake and implementation among populations experiencing health disparities.

Key questions include, but are not limited to:

  • What multilevel interventions and strategies are most effective to increase the reach, access, acceptance, and vaccine completion among racial and ethnic minorities and individuals with lower educational attainment?
  • What multilevel interventions can effectively target individual beliefs, risk perceptions, and behavior to increase vaccine acceptance among persons from racial and ethnic minority groups?
  • How can we adapt evidence-based interventions that have reduced vaccine hesitancy and increased both access and uptake of other vaccinations for all recommended vaccines among children from racial and ethnic minority and low socioeconomic status backgrounds?
  • How can social media, digital marketing, and other innovative technologies be integrated into vaccine promotion interventions to identify and address the sources of misinformation and disinformation regarding vaccination?
  • How can vaccine-related communications on SARS-CoV-2, HPV, influenza, and other vaccines be generated and promoted by clinicians and healthcare systems to be community and/or culturally appropriate?
  • What are effective culturally specific and/or community competent approaches for reducing barriers and increasing vaccination uptake and completion?
  • What service delivery or organizational level policies are effective in facilitating broad vaccination uptake and reducing barriers such as stigma, distrust, fear, discrimination, and exposure to misinformation?
  • What local, state, or federal policies are effective in mitigating disparities in vaccine access, uptake, and series completion?
  • How does scientific uncertainty, including rapidly changing vaccine guidance impact vaccine uptake among racial and ethnic minority and socioeconomically disadvantaged populations?
  • What unintended negative consequences do vaccine related policies create, such as exacerbating disparities in access or vaccine series completion?
  • What are effective dissemination and implementation strategies related to vaccination in clinical and community settings among racial and ethnic minority groups and sexual and gender minorities in rural and urban areas?
  • What rapid data collection methods can be used to identify and prioritize vaccine interventions in communities?

Disparity populations include racial and ethnic minority groups, people with less privileged socioeconomic status, sexual and gender minority persons, and underserved rural populations.


General NIH eligibility includes:

  • Higher education institutions
    • Public/state controlled institutions
    • Private institutions
  • Nonprofit organizations
    • With 501(c)(3) status
    • Without 501(c)(3) status
    • Native American tribal organizations
    • Faith-based or community-based organizations
    • Regional organizations
  • Governments
    • State
    • County
    • City or township
    • Special districts
    • Federally recognized Indian/Native American tribal governments
    • Indian/Native American tribal governments (other than federally recognized)
    • Eligible agencies of the federal government
    • U.S. territory or possession
  • Other
    • Independent school districts
    • Public housing authorities
    • Indian housing authorities
    • Small businesses
    • For-profit organizations

Related funding announcements may have additional eligibility requirements.

Geographic coverage
Nationwide and U.S. Territories
Amount of funding

Funding amounts are based on the related funding announcements.

Application process

This is a NOSI that is attached to related NIH announcements listed on the program website.

Applicants should submit proposals to the related announcement and indicate that it is a response to the NOSI.

Investigators planning to submit an application are strongly encouraged to contact and discuss their proposed research with program staff well in advance of the anticipated submission date to better determine appropriateness and interest.

This NOSI expires on June 6, 2026.

Tagged as
LGBTQ+ · Minorities · Public health · Racial and ethnic groups · Research methods and resources · Vaccination

Organizations (2)

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