AI Frameworks and Guiding Principles
The federal government has created different AI frameworks and resources. This guidance provides a foundation for the safe, effective, transparent, and ethical use of AI. Collectively, these resources include principles for AI governance, including:
- Safety
- Transparency
- Accountability
- Privacy protection
- Human oversight
Within the health sector, several federal agencies have released AI guidance that is relevant to rural healthcare organizations. For example, the Centers for Disease Control and Prevention's (CDC) Vision for AI in Public Health outlines the responsible use of AI to advance public health, and the U.S. Department of Veterans Affairs (VA) Trustworthy AI Framework describes requirements and priorities for AI use. These resources can help rural organizations develop, implement, and monitor AI solutions.
Resources to Learn More
Artificial Intelligence Risk Management
Framework (AI RMF)
Website
Provides a framework to help organizations identify, assess, manage, and communicate risks associated with AI
systems, supporting trustworthy and responsible AI adoption.
Organization(s): National Institute of Standards and Technology
Executive
Order 13960: Promoting the Use of Trustworthy Artificial Intelligence in the Federal Government
Document
Establishes principles for the use of AI by U.S. federal agencies.
Citation: Federal Register, 85, 78939
Date: 12/2020
HHS Artificial Intelligence Use Cases
Inventory
Website
Highlights AI use cases across the U.S. Department of Health and Human Services, including applications in
healthcare delivery, public health, research, and administrative functions.
Organization(s): U.S. Department of Health and Human Services
How CDC is Using AI
Website
Offers examples of CDC programs applying AI and machine learning to support public health practice, including
FluSight (for forecasting flu), AI Community of Practice, and the National Syndromic Surveillance Program.
Organization(s): Centers for Disease Control and Prevention
National
Policy Framework for Artificial Intelligence: Legislative Recommendations
Document
Presents a national framework to guide AI development across a broad range of public sectors.
Organization(s): The White House
Date: 3/2026
U.S.
Code, Title 15, Chapter 119 (National Artificial Intelligence Initiative), Section 9401 (Definitions)
Website
Provides statutory language related to federal coordination, research, and standards for AI.
Organization(s): U.S. Congress