Chronic Disease in Rural America – Resources - Rural Health Information Hub

Cancer in Rural America: Improving Access to Clinical Trials and Quality of Oncologic Care
Discusses the importance of rural populations accessing oncologic clinical trials to decrease cancer morbidity and mortality rates in rural areas. Provides rural versus urban patient data on distance from trial sites as well as prevalence of chronic disease. Suggests strategies and policies to improve access to clinical trials.
Author(s): Joseph M. Unger, Barbara L. McAneny, Raymond U. Osarogiagbon
Citation: CA: A Cancer Journal for Clinicians, 75(4), 341-361
Date: 07/2025
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Lifespan Exposures to Rural-Urban Conditions and Later-Life Cognitive Function
Examines associations between rural or urban residence during childhood and adulthood and cognitive outcomes, including mild cognitive impairment and dementia, among older adults, utilizing 2016 Harmonized Cognitive Assessment Protocol (HCAP) data of 3496 individuals aged 65 years or older.
Author(s): Lingzhi Chu, Yingyan Wu, Heidi Karjalainen, Olivia E Atherton
Citation: Alzheimer's & Dementia, 21(6), e70267
Date: 06/2025
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Development of Chronic Pain and High-Impact Chronic Pain Across the US Rural–Urban Continuum, 2019–2020
Examines the prevalence of chronic pain across large central metro, large fringe metro, medium and small metro, and nonmetropolitan locations in the United States. Utilizes 2019–2020 National Health Interview Survey Longitudinal Cohort (NHIS-LC) data to analyze the severity of pain by demographic variables, region, and rural versus urban location.
Author(s): Feinuo Sun, Yulin Yang, Richard L. Nahin
Citation: Journal of Rural Health, 41(2)
Date: 05/2025
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Uranium Exposure, Hypertension, and Blood Pressure in the Strong Heart Family Study
Examines the correlation between uranium exposure and health conditions such as hypertension and blood pressure changes in rural, tribal communities. Analyzes health status and uranium levels of 1,453 participants in the Strong Heart Family Study. Discusses rock and soil health, groundwater, and surface water contamination as factors in uranium exposure.
Author(s): Kevin P. Patterson, Abigail Onderwyzer Gold, Miranda J. Spratlen, et al.
Citation: Preventing Chronic Disease, 22
Date: 04/2025
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Are HHC Scores a Reliable Health Status Indicator Across Rural and Urban Areas?
Examines differences in Centers for Medicare & Medicaid Services Hierarchical Condition Category (HCC) risk scores between rural and urban Medicare Fee-for-Service (FFS) beneficiaries and analyzes which factors drive observed differences. Features statistics with breakdowns by urban, large rural, small rural, and isolated rural areas for 4 chronic conditions in 2019-2020.
Author(s): Craig D. Holden, Alana Knudson, Marilyn Klug, Samantha Augenbraun, Shena Popat
Date: 04/2025
Sponsoring organization: ETSU/NORC Rural Health Research Center
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Two Modeling Strategies in Analyzing Clustered Time-to-Event Data: The Strong Heart Family Study
Examines the use of the shared frailty and marginal Cox proportional hazards models to study associations between leukocyte telomere length and time-to-incident stroke among 4,635 American Indian study participants from tribal communities in Arizona, Oklahoma, North Dakota, and South Dakota. Discusses effective use of data models for population genetic studies.
Author(s): Heather Willmott, Caroline Gochanour, Kai Ding, et al.
Citation: Preventing Chronic Disease, 22, 240387
Date: 03/2025
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Public Health Research and Program Strategies for Diabetes Prevention and Management
Editorial describing diabetes prevention and management efforts and policy since 1975. Discusses disparities in diabetes prevalence including rural residence. Highlights current and future work in diabetes prevention and management.
Author(s): Shelly-Ann Bowen, Arsham Alamian, Stephen Onufrak
Citation: Preventing Chronic Disease, 22
Date: 03/2025
Sponsoring organization: Centers for Disease Control and Prevention
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Disparities in Cardiovascular Disease Prevalence by Race and Ethnicity, Socioeconomic Status, Urbanicity, and Social Determinants of Health Among Medicare Beneficiaries With Diabetes
Examines demographic disparities in cardiovascular disease prevalence among people with diabetes, utilizing 2015–2019 Medicare Current Beneficiary Survey data. Includes sociodemographic data, including rural-urban comparisons, on crude and adjusted prevalence of myocardial infarction, stroke, and heart failure.
Author(s): Xilin Zhou, Joohyun Park, Deborah B. Rolka, et al.
Citation: Preventing Chronic Disease, 22, 240270
Date: 03/2025
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Screening and Referral Programs for Diabetes and Cardiovascular Disease: Can Community Pharmacists Bridge the Care Gap?
Examines the community-based valued-driven care initiative (CVCI) in community pharmacies to evaluate its effectiveness related to screening and referral (S&R) to treat cardiovascular disease (CVD) and diabetes mellitus (DM). Analyzes patient demographics and success rates of CVD and DM S&R in 6 community pharmacies, with both rural and urban locations represented.
Author(s): Melanie Livet, Amber Watson, Shweta Pathak, et al.
Citation: Exploratory Research in Clinical and Social Pharmacy, 17, 100539
Date: 03/2025
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A Fast Approach for Analyzing Spatio-Temporal Patterns in Ischemic Heart Disease Mortality Across US Counties (1999–2021)
Examines spatio-temporal patterns and county-level trends of ischemic heart disease (IHD) mortality in the United States from 1999 to 2021. Includes county-level U.S. maps presenting IHD trends as well as discussion of geographic and rural versus urban IHD disparities.
Author(s): A. Urdangarin, T. Goicoa, P. Congdon, M.D. Ugarte
Citation: Spatial and Spatio-Temporal Epidemiology, 52, 100700
Date: 02/2025
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